Merkel Cell Carcinoma

PUBLICATIONS from the Nghiem Lab related to Merkel cell carcinoma


Dr Nghiem sees patients Tuesday mornings at the Seattle Cancer Care Alliance. For patient care issues please call: 206-288-2167.

Please also visit our dedicated Merkel cell carcinoma website for more information.

1. Nghiem P, McKee P, Haynes H. Merkel Cell (Cutaneous Neuroendocrine) Carcinoma, Chapter in: Skin Cancer volume of the Atlas of Clinical Oncology, American Cancer Society, BC Decker Inc, Hamilton Ontario, 2001, Pages 127-141.

2. Herbst A, Haynes H, Nghiem P. Adjuvant Radiation and Lymph Node Surgery Should be the Standard of Care for Merkel Cell Carcinoma. J. Am Acad Dermatol. 2002. 46:640-642.

3. Longo MI, Nghiem P. Merkel Cell Carcinoma Treatment with Radiation: A Good Case Despite No Prospective Studies. Arch Dermatol. 2003. 139(12):1641-3.

4. Gupta SG, Wang LC, Penas PF, Gellenthin M, Lee SJ, Nghiem P. Sentinel Lymph Node Biopsy for Evaluation and Treatment of Patients with Merkel Cell Carcinoma: The Dana-Farber Experience and Meta-Analysis of the Literature. Arch Dermatol. 2006. 142(6):685-90.

5. Heath M, Nghiem P. Merkel Cell Carcinoma: If No Breslow, Then What? J Surg Oncol. 2007. 95(8):614-615.

6. Garneski K, Nghiem P. Merkel Cell Carcinoma Adjuvant Therapy: Current Data Support Radiation but Not Chemotherpay. J Am Acad Dermatol. 2007. 57(1):166-9.

7. Jaimes N, Nghiem P. Chapter 120: Merkel Cell Carcinoma. In Wolff K, Katz S, Goldsmith L, Gilcrhrest B, Leffell D, Paller A (Eds), Fitzpatrick's Dermatology in General Medicine. Mosby, 2007.

8. Lemos B, Nghiem P. Merkel Cell Carcinoma: More Deaths but Still no Pathway to Blame. J Invest Dermatol. 2007. 127(9):2100-2103.

9. Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF, Nghiem P: Clinical Characteristics of Merkel Cell Carcinoma at Diagnosis in 195 Patients: the AEIOU Features. J Am Acad Dermatol. 2008. 58(3):375-81.

10. Lemos B, Yu S, and Nghiem P. Case 19-2008: Merkel-Cell Carcinoma. New England Journal of Medicine. 2008. 358:2717-2723.

11. Paulson K, Lemos B, Feng B, Jaimes N, Penas P, Bi X, Maher E, Cohen L, Leonard J, Granter S, Chin L and Nghiem P. Array-CGH Reveals Recurrent Genomic Changes in Merkel Cell Carcinoma Including Amplification of L-Myc. J Invest Dermatol. 2009. 129(6):1547-55. 

12. Garneski KM, Decaprio JA, Nghiem P. Does a new polyomavirus contribute to Merkel cell carcinoma? Genome Biol. 2008. 9(6):228. 

13. Garneski KM, Warcola AH, Feng Q, Kiviat N, Leonard JH, Nghiem P. Merkel Cell Polyomavirus Is More Frequently Present in North American than Australian Merkel Cell Carcinoma Tumors. J Invest Dermatol. 2009; 129, 246–248.

14. Iyer J, Nghiem P. Merkel Cell Carcinoma: An Uncommon But Often Lethal Skin Cancer. Skin Cancer Foundation Journal. 2009.

15. Carter J, Paulson K, Wipf G, Miranda D, Madeleine M, Johnson L, Lemos B, Lee S, Warcola A, Iyer J, Nghiem P, Galloway D. Association of Merkel Cell Polyomavirus–Specific Antibodies With Merkel Cell Carcinoma. J Nat Cancer Inst. 2009.  

16. Iyer J, Koba S, Nghiem P. Toward Better Management of Merkel Cell Carcinoma Using a Consensus Staging System, New Diagnostic  Codes and a Recently Discovered Virus. Actas Dermosifiliogr. 2009. 100:Supl. 2:49-54.

17. Lemos B, Storer B, Iyer J, Phillips J, Bichakjian C, Fang C, Johnson T, Liegeois-Kwon N, Otley C, Paulson K, Ross M, Yu S, Zeitouni N, Byrd D, Sondak V, Gershenwald J, Sober A, Nghiem P. Pathological nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: Analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol. 2010.

18. Fang C, Lemos B, Douglas J, Iyer J, Nghiem P. Radiation monotherapy as regional treatment for lymph node-positive Merkel cell carcinoma. Cancer. 2010; 116(7):1783-90.  

19. Rao P, Lemos BD, Liegeois NJ, McNiff JM, Nghiem P, Prieto VG, Smith T, Smoller BR, Wick MR, Frishberg DP. Protocol for the Examination of Specimens From Patient With Merkel Cell Carcinoma of the Skin. Arch Pathol Lab Med. 2010; 134: 341-44.

20.  Paulson KG, Carter JJ, Johnson LG, Cahill KW, Iyer JG, Schrama D, Becher JC, Madeleine MM, Nghiem P, Galloway DA. Antibodies to Merkel Cell Polyomavirus T Antigen Oncoproteins Reflect Tumor Burden in Merkel Cell Carcinoma Patients. Cancer Res. 2010; 70: 8388-97.

21.  Izikson L, Nornhold E, Iyer JG, Nghiem P, Zeitouni NC. Merkel cell carcinoma associated with HIV: review of 14 patients. AIDS. Jan 2011, 2;25(1):119-21. doi: 10.1097/QAD.0b013e328340a19c.

22.  Iyer J, Afanasiev O, McClurkan C, Paulson K, Nagase K, Jing L, Marshak JO, Dong L, Carter J, Lai I, Farrar E, Byrd D, Galloway D, Yee C, Koelle DM, Nghiem P. Merkel Cell Polyomavirus-Specific CD8 and CD4 T-cell Responses Identified in Merkel Cell Carcinomas and Blood. Cancer Res. 2011; 17(21):6671-80.

23.  Bhatia S, Afanasiev O, Nghiem P. Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer. Current Oncology Reports.

24.  Paulson KG, Iyer JG, Tegeder AR, Thibodeau R, Schelter J, Koba S, Schrama D, Simonson WT, Lemos BD, Byrd DR, Koelle DM, Galloway DA, Leonard JH, Madeleine MM, Argenyi AB, Disis ML, Becker JC, Cleary MA, Nghiem P. Transcriptome-wide studies of Merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival. J Clin Oncol. 29:1539-46, 2011.

25.  Paulson KG, Iyer JG, Nghiem P. Asymmetric lateral distribution of melanoma and Merkel cell carcinoma in the United States. J Am Acad Dermatology. 65:35-9, 2011.

26.  Koba S, Paulson KG, Nagase K, Tegeder A, Thibodeau R, Iyer JG, Narisawa Y, Nghiem P. Diagnostic biopsy does not commonly induce intratumoral CD8 T cell infiltration in Merkel cell carcinoma. PLoS ONE 7(7): e41465. July 2012, doi:10.1371/journal.pone.0041465

27.  Lee S, Paulson KG, Murchison EP, Afanasiev OK, Alkan C, Leonard JH, Byrd DR, Hannon GJ, Nghiem PT. Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas. J Clin Virol, 52(3): 272–275. doi:10.1016/j.jcv.2011.08.012. Nov 2011. PMID: 21907614. PMCID: PMC3196837

28.  Vandeven N, Nghiem P. Complete Spontaneous Regression of Merkel Cell Carcinoma Metastatic to the Liver: Did Lifestyle Modifications and Dietary Supplements Play a Role? Glob Adv Health Med. 1(5):20-21, Nov 2012.

29.  Paulson KG*, Iyer JG*, Blom A, Warton EM, Sokil M, Yelistratova L, Schuman L Nagase K, Bhatia S, Asgari MM, Nghiem P. Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage. *Equal contribution. J Invest Dermatol. Nov 29, 2012. doi: 10.1038/jid.2012.388.

30. Miller NJ, Bhatia S, Parvathaneni U, Iyer JG, Nghiem P. Emerging and mechanism-based therapies for recurrent or metastatic Merkel cell carcinoma. Curr Treat Options Oncol. 2013.

31. Afanasiev OK, Nagase K, Simonson W, Vandeven N, Blom A, Koelle DM, Clark R, Nghiem P.  Vascular E-selectin expression correlates with CD8 lymphocyte infiltration and improved outcome in Merkel cell carcinoma. J Invest Dermatol, Aug 2013;133(8): 2065-73. Article highlighted in associated Commentary by Feldmeyer et al, pp 1929.

32. Dowlatshahi M, Huang V, Gehad A, Jiang Y, Calarese A, Teague JE, Dorosario A, Cheng J, Nghiem P, Schanbacher C, Thakuria M, Schmults C, Wang LC, Clark RA.  Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T cell exhaustion in reducing T cell responses. J Invest Dermatol. 2013 Jul;133(7):1879-89. 

33. Paulson KG*, Iyer JG*, Blom A, Warton EM, Sokil M, Yelistratova L, Schuman L Nagase K, Bhatia S, Asgari MM, Nghiem P.  Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage. *Equal contribution. J Invest Dermatol. March 2013;133(3):642-6.

34. Cheng J, Rozenblatt-Rosen O, Paulson KG, Nghiem P, DeCaprio JA.  Merkel cell polyomavirus large T antigen has growth promoting and inhibitory activities. J Virol, 2013 Jun;87(11):6118-26.

35. Koba S, Paulson KG, Nagase K, Tegeder A, Thibodeau R, Iyer JG, Narisawa Y, Nghiem P.  Diagnostic biopsy does not commonly induce intratumoral CD8 T cell infiltration in Merkel cell carcinoma. PLoS ONE, 2012;7(7). doi:10.1371/ Epub Oct 16, 2013.

36. Conney AH, Lu Y-P, Lou Y-R, Kawasumi M, Nghiem P.  Mechanisms of caffeine-induced inhibition of UBV carcinogenesis. Frontiers in Oncology, June 17, 2013.

37. Afanasiev OK, Yelistratova L, Miller N, Nagase K, Paulson KG, Iyer JG, Ibrani D, Koelle DM, Nghiem P. Merkel cell polyomavirus-specific T cells fluctuate with Merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers.  Clin Cancer Res; 19(19); 5351–60. 2013 Oct.

38. Paulson KG, Iyer JG, Byrd DR, Nghiem P. Pathologic nodal evaluation is increasingly commonly performed for patients with Merkel cell carcinoma. J Am Acad Dermatol. 2013 Oct;69(4):653-4. doi: 10.1016/j.jaad.2013.

39. Stetsenko Gy, Malekirad J, Paulson KG, Iyer JG; Thibodeau Rm, Nagase K, Schmidt M, Storer BE, Argenyi ZB; Nghiem P.  p63 expression in Merkel cell carcinoma predicts poorer survival yet may have limited clinical utility.  Am J Clin Pathol. 2013 Dec;140(6):838-44.

40. Chapuis AG, Afanasiev OK, Iyer JG, Paulson KG, Parvathaneni U, Hwang JH, Lai I, Roberts IM, Sloan HL, Bhatia S, Shibuya KC, Gooley T, Desmarais C, Koelle DM, Yee C, Nghiem P. Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of reinducing HLA class-I. Cancer Immunol Res, 2(1) January 2014.

41. Vandeven N, Nghiem P. Pathogen-driven cancers and emerging immune therapeutic strategies. Cancer Immunol Res. January 2014.

42. Blom A, Bhatia S, Pietromonaco S, Koehler K, Iyer JG, Nagase K, Paulson K, Sabath DE, Nghiem P. Clinical utility of a circulating tumor cell assay in Merkel cell carcinoma. J Am Acad Dermatol. 2014 Mar;70(3):449-55. doi: 10.1016/j.jaad.2013.10.051. Epub 2013 Dec 31.

43. Lyngaa R, Pedersen NW, Schrama D, Thrue CA, Ibrani D, Met Ö, Thor Straten P, Nghiem P, Becker JC, Hadrup SR. T-cell Responses to Oncogenic Merkel Cell Polyomavirus Proteins Distinguish Patients with Merkel Cell Carcinoma from Healthy Donors. Clin Cancer Res. 2014 Mar 13.

44. Iyer, JG, Storer, BE, Paulson, KG, Lemos, B, Phillips, JL, Bichakjian C, Zeitouni N, Gershenwald JE, Sondak V, Otley CC, Yu SS, Johnson TM, Liegeois NJ, Byrd D, Sober A, Nghiem P. Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma. (Recommended by Faculty of 1000 Ltd) J Am Acad Dermatol. 2014 Apr;70(4):637-43.

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