Merkel Cell Carcinoma

PUBLICATIONS from the Nghiem Lab related to Merkel cell carcinoma

 

Dr Nghiem sees patients Tuesday mornings at the Seattle Cancer Care Alliance. For patient care issues please call: 206-288-1062.

Please also visit our dedicated Merkel cell carcinoma website for more information.

1. Nghiem P, McKee P, Haynes H. Merkel Cell (Cutaneous Neuroendocrine) Carcinoma, Chapter in: Skin Cancer volume of the Atlas of Clinical Oncology, American Cancer Society, BC Decker Inc, Hamilton Ontario, 2001, Pages 127-141.

2. Herbst A, Haynes H, Nghiem P. Adjuvant Radiation and Lymph Node Surgery Should be the Standard of Care for Merkel Cell Carcinoma. J. Am Acad Dermatol. 2002. 46:640-642.

3. Longo MI, Nghiem P. Merkel Cell Carcinoma Treatment with Radiation: A Good Case Despite No Prospective Studies. Arch Dermatol. 2003. 139(12):1641-3.

4. Gupta SG, Wang LC, Penas PF, Gellenthin M, Lee SJ, Nghiem P. Sentinel Lymph Node Biopsy for Evaluation and Treatment of Patients with Merkel Cell Carcinoma: The Dana-Farber Experience and Meta-Analysis of the Literature. Arch Dermatol. 2006. 142(6):685-90.

5. Heath M, Nghiem P. Merkel Cell Carcinoma: If No Breslow, Then What? J Surg Oncol. 2007. 95(8):614-615.

6. Garneski K, Nghiem P. Merkel Cell Carcinoma Adjuvant Therapy: Current Data Support Radiation but Not Chemotherpay. J Am Acad Dermatol. 2007. 57(1):166-9.

7. Jaimes N, Nghiem P. Chapter 120: Merkel Cell Carcinoma. In Wolff K, Katz S, Goldsmith L, Gilcrhrest B, Leffell D, Paller A (Eds), Fitzpatrick's Dermatology in General Medicine. Mosby, 2007.

8. Lemos B, Nghiem P. Merkel Cell Carcinoma: More Deaths but Still no Pathway to Blame. J Invest Dermatol. 2007. 127(9):2100-2103.

9. Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF, Nghiem P: Clinical Characteristics of Merkel Cell Carcinoma at Diagnosis in 195 Patients: the AEIOU Features. J Am Acad Dermatol. 2008. 58(3):375-81.

10. Lemos B, Yu S, and Nghiem P. Case 19-2008: Merkel-Cell Carcinoma. New England Journal of Medicine. 2008. 358:2717-2723.

11. Paulson K, Lemos B, Feng B, Jaimes N, Penas P, Bi X, Maher E, Cohen L, Leonard J, Granter S, Chin L and Nghiem P. Array-CGH Reveals Recurrent Genomic Changes in Merkel Cell Carcinoma Including Amplification of L-Myc. J Invest Dermatol. 2009. 129(6):1547-55. 

12. Garneski KM, Decaprio JA, Nghiem P. Does a new polyomavirus contribute to Merkel cell carcinoma? Genome Biol. 2008. 9(6):228. 

13. Garneski KM, Warcola AH, Feng Q, Kiviat N, Leonard JH, Nghiem P. Merkel Cell Polyomavirus Is More Frequently Present in North American than Australian Merkel Cell Carcinoma Tumors. J Invest Dermatol. 2009; 129, 246–248.


14. Iyer J, Nghiem P. Merkel Cell Carcinoma: An Uncommon But Often Lethal Skin Cancer. Skin Cancer Foundation Journal. 2009.

15. Carter J, Paulson K, Wipf G, Miranda D, Madeleine M, Johnson L, Lemos B, Lee S, Warcola A, Iyer J, Nghiem P, Galloway D. Association of Merkel Cell Polyomavirus–Specific Antibodies With Merkel Cell Carcinoma. J Nat Cancer Inst. 2009.  

16. Iyer J, Koba S, Nghiem P. Toward Better Management of Merkel Cell Carcinoma Using a Consensus Staging System, New Diagnostic  Codes and a Recently Discovered Virus. Actas Dermosifiliogr. 2009. 100:Supl. 2:49-54.

17. Lemos B, Storer B, Iyer J, Phillips J, Bichakjian C, Fang C, Johnson T, Liegeois-Kwon N, Otley C, Paulson K, Ross M, Yu S, Zeitouni N, Byrd D, Sondak V, Gershenwald J, Sober A, Nghiem P. Pathological nodal evaluation improves prognostic accuracy in Merkel cell carcinoma: Analysis of 5823 cases as the basis of the first consensus staging system. J Am Acad Dermatol. 2010.

18. Fang C, Lemos B, Douglas J, Iyer J, Nghiem P. Radiation monotherapy as regional treatment for lymph node-positive Merkel cell carcinoma. Cancer. 2010; 116(7):1783-90.  

19. Rao P, Lemos BD, Liegeois NJ, McNiff JM, Nghiem P, Prieto VG, Smith T, Smoller BR, Wick MR, Frishberg DP. Protocol for the Examination of Specimens From Patient With Merkel Cell Carcinoma of the Skin. Arch Pathol Lab Med. 2010; 134: 341-44.

20.  Paulson KG, Carter JJ, Johnson LG, Cahill KW, Iyer JG, Schrama D, Becher JC, Madeleine MM, Nghiem P, Galloway DA. Antibodies to Merkel Cell Polyomavirus T Antigen Oncoproteins Reflect Tumor Burden in Merkel Cell Carcinoma Patients. Cancer Res. 2010; 70: 8388-97.

21.  Izikson L, Nornhold E, Iyer JG, Nghiem P, Zeitouni NC. Merkel cell carcinoma associated with HIV: review of 14 patients. AIDS. Jan 2011, 2;25(1):119-21. doi: 10.1097/QAD.0b013e328340a19c.

22.  Iyer J, Afanasiev O, McClurkan C, Paulson K, Nagase K, Jing L, Marshak JO, Dong L, Carter J, Lai I, Farrar E, Byrd D, Galloway D, Yee C, Koelle DM, Nghiem P. Merkel Cell Polyomavirus-Specific CD8 and CD4 T-cell Responses Identified in Merkel Cell Carcinomas and Blood. Cancer Res. 2011; 17(21):6671-80.

23.  Bhatia S, Afanasiev O, Nghiem P. Immunobiology of Merkel cell carcinoma: implications for immunotherapy of a polyomavirus-associated cancer. Current Oncology Reports.

24.  Paulson KG, Iyer JG, Tegeder AR, Thibodeau R, Schelter J, Koba S, Schrama D, Simonson WT, Lemos BD, Byrd DR, Koelle DM, Galloway DA, Leonard JH, Madeleine MM, Argenyi AB, Disis ML, Becker JC, Cleary MA, Nghiem P. Transcriptome-wide studies of Merkel cell carcinoma and validation of intratumoral CD8+ lymphocyte invasion as an independent predictor of survival. J Clin Oncol. 29:1539-46, 2011.

25.  Paulson KG, Iyer JG, Nghiem P. Asymmetric lateral distribution of melanoma and Merkel cell carcinoma in the United States. J Am Acad Dermatology. 65:35-9, 2011.

26.  Koba S, Paulson KG, Nagase K, Tegeder A, Thibodeau R, Iyer JG, Narisawa Y, Nghiem P. Diagnostic biopsy does not commonly induce intratumoral CD8 T cell infiltration in Merkel cell carcinoma. PLoS ONE 7(7): e41465. July 2012, doi:10.1371/journal.pone.0041465

27.  Lee S, Paulson KG, Murchison EP, Afanasiev OK, Alkan C, Leonard JH, Byrd DR, Hannon GJ, Nghiem PT. Identification and validation of a novel mature microRNA encoded by the Merkel cell polyomavirus in human Merkel cell carcinomas. J Clin Virol, 52(3): 272–275. doi:10.1016/j.jcv.2011.08.012. Nov 2011. PMID: 21907614. PMCID: PMC3196837

28.  Vandeven N, Nghiem P. Complete Spontaneous Regression of Merkel Cell Carcinoma Metastatic to the Liver: Did Lifestyle Modifications and Dietary Supplements Play a Role? Glob Adv Health Med. 1(5):20-21, Nov 2012.

29.  Paulson KG*, Iyer JG*, Blom A, Warton EM, Sokil M, Yelistratova L, Schuman L Nagase K, Bhatia S, Asgari MM, Nghiem P. Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage. *Equal contribution. J Invest Dermatol. Nov 29, 2012. doi: 10.1038/jid.2012.388.

30. Miller NJ, Bhatia S, Parvathaneni U, Iyer JG, Nghiem P. Emerging and mechanism-based therapies for recurrent or metastatic Merkel cell carcinoma. Curr Treat Options Oncol. 2013.

31. Afanasiev OK, Nagase K, Simonson W, Vandeven N, Blom A, Koelle DM, Clark R, Nghiem P.  Vascular E-selectin expression correlates with CD8 lymphocyte infiltration and improved outcome in Merkel cell carcinoma. J Invest Dermatol, Aug 2013;133(8): 2065-73. Article highlighted in associated Commentary by Feldmeyer et al, pp 1929.

32. Dowlatshahi M, Huang V, Gehad A, Jiang Y, Calarese A, Teague JE, Dorosario A, Cheng J, Nghiem P, Schanbacher C, Thakuria M, Schmults C, Wang LC, Clark RA.  Tumor-specific T cells in human Merkel cell carcinomas: a possible role for Tregs and T cell exhaustion in reducing T cell responses. J Invest Dermatol. 2013 Jul;133(7):1879-89. 

33. Paulson KG*, Iyer JG*, Blom A, Warton EM, Sokil M, Yelistratova L, Schuman L Nagase K, Bhatia S, Asgari MM, Nghiem P.  Systemic immune suppression predicts diminished Merkel cell carcinoma-specific survival independent of stage. *Equal contribution. J Invest Dermatol. March 2013;133(3):642-6.

34. Cheng J, Rozenblatt-Rosen O, Paulson KG, Nghiem P, DeCaprio JA.  Merkel cell polyomavirus large T antigen has growth promoting and inhibitory activities. J Virol, 2013 Jun;87(11):6118-26.

35. Koba S, Paulson KG, Nagase K, Tegeder A, Thibodeau R, Iyer JG, Narisawa Y, Nghiem P.  Diagnostic biopsy does not commonly induce intratumoral CD8 T cell infiltration in Merkel cell carcinoma. PLoS ONE, 2012;7(7). doi:10.1371/ Epub Oct 16, 2013.

36. Conney AH, Lu Y-P, Lou Y-R, Kawasumi M, Nghiem P.  Mechanisms of caffeine-induced inhibition of UBV carcinogenesis. Frontiers in Oncology, June 17, 2013.

37. Afanasiev OK, Yelistratova L, Miller N, Nagase K, Paulson KG, Iyer JG, Ibrani D, Koelle DM, Nghiem P. Merkel cell polyomavirus-specific T cells fluctuate with Merkel cell carcinoma burden and express therapeutically targetable PD-1 and Tim-3 exhaustion markers.  Clin Cancer Res; 19(19); 5351–60. 2013 Oct.

38. Paulson KG, Iyer JG, Byrd DR, Nghiem P. Pathologic nodal evaluation is increasingly commonly performed for patients with Merkel cell carcinoma. J Am Acad Dermatol. 2013 Oct;69(4):653-4. doi: 10.1016/j.jaad.2013.

39. Stetsenko Gy, Malekirad J, Paulson KG, Iyer JG; Thibodeau Rm, Nagase K, Schmidt M, Storer BE, Argenyi ZB; Nghiem P.  p63 expression in Merkel cell carcinoma predicts poorer survival yet may have limited clinical utility.  Am J Clin Pathol. 2013 Dec;140(6):838-44.

40. Chapuis AG, Afanasiev OK, Iyer JG, Paulson KG, Parvathaneni U, Hwang JH, Lai I, Roberts IM, Sloan HL, Bhatia S, Shibuya KC, Gooley T, Desmarais C, Koelle DM, Yee C, Nghiem P. Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of reinducing HLA class-I. Cancer Immunol Res, 2(1) January 2014.

41. Vandeven N, Nghiem P. Pathogen-driven cancers and emerging immune therapeutic strategies. Cancer Immunol Res. January 2014.

42. Blom A, Bhatia S, Pietromonaco S, Koehler K, Iyer JG, Nagase K, Paulson K, Sabath DE, Nghiem P. Clinical utility of a circulating tumor cell assay in Merkel cell carcinoma. J Am Acad Dermatol. 2014 Mar;70(3):449-55. doi: 10.1016/j.jaad.2013.10.051. Epub 2013 Dec 31.

43. Lyngaa R, Pedersen NW, Schrama D, Thrue CA, Ibrani D, Met Ö, Thor Straten P, Nghiem P, Becker JC, Hadrup SR. T-cell Responses to Oncogenic Merkel Cell Polyomavirus Proteins Distinguish Patients with Merkel Cell Carcinoma from Healthy Donors. Clin Cancer Res. 2014 Mar 13.

44. Iyer, JG, Storer, BE, Paulson, KG, Lemos, B, Phillips, JL, Bichakjian C, Zeitouni N, Gershenwald JE, Sondak V, Otley CC, Yu SS, Johnson TM, Liegeois NJ, Byrd D, Sober A, Nghiem P. Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma. (Recommended by Faculty of 1000 Ltd) J Am Acad Dermatol. 2014 Apr;70(4):637-43.

45. Paulson KG, Tegeder A, Willmes C, Iyer JG, Afanasiev OK, Schrama D, Koba S, Thibodeau R, Nagase K, Simonson WT, Seo A, Koelle DM, Madeleine M, Bhatia S, Nakajima H, Sano S, Hardwick JS, Disis ML, Cleary MA, Becker JC, Nghiem P. Downregulation of MHC-I expression is prevalent but reversible in Merkel cell carcinoma. Cancer Immunol Res. 2014 Nov;2(11):1071-9. CIR-14-0005. Epub 2014 Aug 12. PMID:25116754.

46. Chapuis AG, Afanasiev OK, Iyer JG, Paulson KG, Parvathaneni U, Hwang JH, Lai I, Roberts IM, Sloan HL, Bhatia S, Shibuya KC, Gooley T, Desmarais C, Koelle DM, Yee C, Nghiem P. Regression of metastatic Merkel cell carcinoma following transfer of polyomavirus-specific T cells and therapies capable of reinducing HLA class-I. Cancer Immunol Res, 2(1) January 2014, PMID:24432305, PMCID: PMC3888869

47. Vandeven N, Nghiem P. Pathogen-driven cancers and emerging immune therapeutic strategies. Cancer Immunol Res. 2014 Jan;2(1):9-14. PMID:24778160

48. Blom A, Bhatia S, Pietromonaco S, Koehler K, Iyer JG, Nagase K, Paulson K, Sabath DE, Nghiem P. Clinical utility of a circulating tumor cell assay in Merkel cell carcinoma. J Am Acad Dermatol. 2014 Mar;70(3):449-55. Epub 2013 Dec 31. PMID: 24388423

49. Lyngaa R, Pedersen NW, Schrama D, Thrue CA, Ibrani D, Met Ö, Thor Straten P, Nghiem P, Becker JC, Hadrup SR. T-cell Responses to Oncogenic Merkel Cell Polyomavirus Proteins Distinguish Patients with Merkel Cell Carcinoma from Healthy Donors. Clin Cancer Res. 2014 Mar 13 PMID: 24526738

50. Iyer, JG, Storer, BE, Paulson, KG, Lemos, B, Phillips, JL, Bichakjian C, Zeitouni N, Gershenwald JE, Sondak V, Otley CC, Yu SS, Johnson TM, Liegeois NJ, Byrd D, Sober A, Nghiem P. Relationships among primary tumor size, number of involved nodes, and survival for 8044 cases of Merkel cell carcinoma. J Am Acad Dermatol. 2014 Apr;70(4):637-43. PMID: 24521828 PMCID: PMC3959572

51. Asgari MM, Sokil MM, Warton EM, Iyer J, Paulson KG, Nghiem P. Effect of host, tumor, diagnostic, and treatment variables on outcomes in a large cohort with Merkel cell carcinoma. JAMA Dermatol. 2014 Jul;150(7):716-23. PMID: 24807619; PMCID: PMC4141075

52. Moshiri AS, Nghiem P. Milestones in the staging, classification, and biology of Merkel cell carcinoma. J Natl Compr Canc Netw. 2014 Sep;12(9):1255-62. PMID: 25190694; PMCID: PMC4161960

53. Paulson KG, Iyer JG, Simonson WT, Blom A, Thibodeau RM, Schmidt M, Pietromonaco S, Sokil M, Warton EM, Asgari MM, Nghiem P. CD8+ lymphocyte intratumoral infiltration as a stage-independent predictor of Merkel cell carcinoma survival: a population-based study. Am J Clin Pathol. 2014 Oct;142(4):452-8. PMID: 25239411; PMCID: PMC4174450

54. Kawasumi M, Bradner JE, Tolliday N, Thibodeau R, Sloan H, Brummond KM, Nghiem P. Identification of ATR-Chk1 Pathway Inhibitors That Selectively Target p53-Deficient Cells without Directly Suppressing ATR Catalytic Activity. Cancer Res. 2014 Dec 15;74(24):7534-45. Epub 2014 Oct 21. PMID: 25336189; PMCID: PMC4268153

55. Nghiem P. Merkel Cell Carcinoma: Intersection of Immune Dysfunction, Infection, and Malignant Progression. J Investig Dermatol Symp Proc. 2015 Jul;17(1):36. doi: 10.1038/jidsymp.2015.12. PMID: 26067317.

56. Iyer JG, Parvathaneni U, Gooley T, Miller NJ, Markowitz E, Blom A, Lewis CW, Doumani RF, Parvathaneni K, Anderson A, Bestick A, Liao J, Kane G, Bhatia S, Paulson K, Nghiem P. Single fraction radiation therapy in patients with metastatic Merkel cell carcinoma. Cancer Medicine. 2015 Aug;4(8):1161-70. PMID: 25908228; PMCID: PMC4559027

57. Church C., Nghiem P. How does the Merkel polyomavirus transform cells? Many answers, many questions, and a new mouse model. J Invest Dermatol. 2015 May;135(5):1221-4. PMID: 25882464; PMCID: PMC4402710

58. Shantha E, Lewis C, Nghiem P. Why Do Airline Pilots and Flight Crews Have an Increased Incidence of Melanoma? JAMA Oncol. 2015 Sep;1(6):829-30. PMID: 26181192.

59. Mutational landscape of MCPyV-positive and MCPyV-negative merkel cell carcinomas with implications for immunotherapy. Goh G, et al. Oncotarget. 2015 Dec 7. doi: 10.18632/oncotarget.6494. PMID: 26655088; PMCID: PMC4823115.

60. Ritter C, Fan K, Paulson KG, Nghiem P, Schrama D, Becker JC. Reversal of epigenetic silencing of MHC class I chain-related protein A and B improves immune recognition of Merkel cell carcinoma. 2016 February 23. PMCID: PMC4763224.

61. Nghiem PT, Bhatia S, Lipson EJ, Kudchadkar RR, Miller NJ, Annamalai L, Berry S, Chartash EK, Daud A, Fling SP, Friedlander PA, Kluger HM, Kohrt HE, Lundgren L, Margolin K, Mitchell A, Olencki T, Pardoll DM, Reddy SA, Shantha EM, Sharfman WH, Sharon E, Shemanski LR, Shinohara MM, Sunshine JC, Taube JM, Thompson JA, Townson SM, Yearley JH, Topalian SL, Cheever MA. PD-1 Blockade with Pembrolizumab in Advanced Merkel-Cell Carcinoma. N Engl J Med. 2016 Apr 19. PMID: 27093365.

62. Iyer JG, Parvathaneni K, Bhatia S, Tarabadkar ES, Blom A, Doumani R, McKenzie J, Asgari MM, Nghiem P. Paraneoplastic syndromes (PNS) associated with Merkel cell carcinoma (MCC): A case series of 8 patients highlighting different clinical manifestations. J Am Acad Dermatol. 2016 May 11. pii: S0190-9622(16)30145-1. doi: 10.1016/j.jaad.2016.04.040. PMID: 27177440.

63. Bhatia S, Storer BE, Iyer JG, Moshiri A, Parvathaneni U, Byrd D, Sober AJ, Sondak VK, Gershenwald JE, Nghiem P. Adjuvant Radiation Therapy and Chemotherapy in Merkel Cell Carcinoma: Survival Analyses of 6908 Cases From the National Cancer Data Base. J Natl Cancer Inst. 2016 May 31;108(9). pii: djw042. doi: 10.1093/jnci/djw042. Print 2016 Sep. PubMed PMID: 27245173.

64. Vandeven NA1, Nghiem P2. Merkel Cell Carcinoma: An Unusually Immunogenic Cancer Proves Ripe for Immune Therapy. J Oncol Pract. 2016 Jul;12(7):649-50. doi: 10.1200/JOP.2016.014498.

65. Vandeven N1, Nghiem P1. Rationale for immune-based therapies in Merkel polyomavirus-positive and -negative Merkel cell carcinomas. Immunotherapy. 2016 Jul;8(8):907-21. doi: 10.2217/imt-2016-0009.

66. Iyer JG1, Blom A1, Doumani R1, Lewis C1, Tarabadkar ES1, Anderson A1, Ma C1, Bestick A1, Parvathaneni U2, Bhatia S3, Nghiem P4. Response rates and durability of chemotherapy among 62 patients with metastatic Merkel cell carcinoma. Cancer Med. 2016 Sep;5(9):2294-301. doi: 10.1002/cam4.815. Epub 2016 Jul 19.

67. Axel Hauschild, Dirk Schadendorf, Checkpoint inhibitors: a new standard of care for advanced Merkel cell carcinoma?, The Lancet Oncology, Avail online 1 September 2016, ISSN 1470-2045, http://dx.doi.org/10.1016/S1470-2045(16)30441-7. http://www.sciencedirect.com/science/article/pii/S1470204516304417

68. Kaufman HL, Russell J, Hamid O, Bhatia S, Terheyden P, D'Angelo SP, Shih KC, Lebbé C, Linette GP, Milella M, Brownell I, Lewis KD, Lorch JH, Chin K, Mahnke L, von Heydebreck A, Cuillerot JM, Nghiem P. Avelumab in patients with chemotherapy-refractory metastatic Merkel cell carcinoma: a multicentre, single-group, open-label, phase 2 trial. Lancet Oncol. 2016 Sep 1. pii: S1470-2045(16)30364-3. doi: 10.1016/S1470-2045(16)30364-3. PMID: 27592805.

69. Mullen TD1, Nghiem P2, Bhatia S2, Parvathaneni U3, Schwartz JL4. Merkel Cell Carcinoma Cell Death in Response to Single-Fraction Irradiation: Implications for Immune Therapy. Int J Radiat Oncol Biol Phys. 2016 Oct 1;96(2S):E714. doi: 10.1016/j.ijrobp.2016.06.2418. PMID: 27675438.

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