Basic Research Publications

(Clinical Publications listed separately)

  1. Itoh T, Rao A, O'Brien D, Nghiem P, Cantor H. Limiting Dilution Analysis of Ontogeny of Self- and Allo-Reactive Thymocytes of C57BL/6J Mouse. Thymus. 16:89-98, 1990.

  2. Nghiem P. Use of Highly Degenerate Primers to Amplify and Sequence Novel Target cDNA's. U. S. Biochemical Comments. 17(2):22-23, 1990.

  3. Maldonado D, Schumann M, Nghiem P, Dong Y, Gardner P. Prostaglandin E1 Activates a Chloride Current in Jurkat T Lymphocytes via cAMP-Dependent Protein Kinase. FASEB J. 5:2965-2970, 1991.

  4. Wagner JA, McDonald TV, Nghiem P, Lowe AW, Schulman H, Gruenert DC, Stryer L, Gardner P. Antisense Oligodeoxynucleotides to the Cystic Fibrosis Transmembrane Conductance Regulator Inhibit cAMP-activated but not Calcium-activated Chloride Currents. Proc. Natl. Acad. Sci. USA. 89: 6785-6789, 1992. [pdf]

  5. McDonald TV, Nghiem P, Gardner P, Martens CL. Human Lymphocytes Transcribe the Cystic Fibrosis Transmembrane Conductance Regulator Gene and Exhibit CF-defective cAMP-regulated Chloride Current. J. Biol. Chem. 267:3242-3248, 1992. [pdf]

  6. Paul Nghiem, Shahin Saati, Chris Martens, Phyllis Gardner, Howard Schulman. Cloning and Analysis of Two New Isoforms of Multifunctional Calcium/Calmodulin-dependent Protein Kinase Expressed in Multiple Human Tissues. J. Biol. Chem. 268: 5471-5479, 1993. [pdf]

  7. Li X, Nghiem P, Schulman H, Francke U. Localization of the CAMKG Gene Encoding Gamma Isoforms of Multifunctional Calcium/calmodulin-dependent Protein Kinase (CaM Kinase) to Human Chromosome 10 Band q22 and Mouse Chromosome 14. Cytogenet. Cell Genet. 66:113-116, 1994.

  8. Nghiem P, Ollick TN, Gardner PI, Schulman H. Interleukin-2 Transcriptional Block by Multifunctional CaM Kinase. Nature. 371:347-350, 1994.

  9. * Nghiem P. Identifying the Missing Link Between UV and p53: The Role of Phosphatidyl Inositol Kinase-Related Kinases. J. Am. Acad. Dermatol. 43(4):706-707, 2000. [pdf]

  10. Choi C, Nghiem P. Tacrolimus Ointment in the Treatment of Chronic Cutaneous Graft-vs-Host Disease: A Case Series of 18 Patients. Arch. Dermatol. 137:75-76 , 2001. [pdf]

  11. ** Nghiem P, Park P, Kim Y, Vaziri C, Schreiber S. ATR Inhibition Selectively Sensitizes G1 Checkpoint-Deficient Cells to Lethal Premature Chromatin Condensation. Proc. Natl. Acad. Sci. USA. 98:9092-9098, 2001. [pdf]

  12. ** Nghiem P, Park P, Kim Y, Desai B, Taya Y, Schreiber S. ATR is Not Required for p53 Activation but Synergizes with p53 in the Replication Checkpoint. J. Biol. Chem. 277:4428-4434, 2002. [pdf]

  13. ** Casper A, Nghiem P, Arlt M, Glover T. ATR Regulates Fragile Site Stability. Cell 111:779-789, 2002. [pdf]

  14. ** Roshal M, Kim B, Zhu Y, Nghiem P, Planelles V. Activation of the ATR-mediated DNA damage response by the HIV-1 Viral protein R. J Biol Chem. 278:25879-25886, 2003. [pdf]

  15. Shamji, A, Nghiem, P, Schreiber, S. Integration of Growth Factor and Nutrient Signaling: Implications for Cancer Biology. Molecular Cell, 12:271-280, 2003. [pdf]

  16. * Nghiem, P, Kim, Y., Schreiber, S. Protein Kinases as Targets in Cancer Therapy: Validated and Emerging Approaches. Chapter 13, pages 293-315: Oncogenomics: Molecular Approaches to Cancer. Eds: Brenner, C & Duggan, D. John Wiley and Sons Publisher, 2004. [pdf]

  17. Zimmerman ES, Chen J, Andersen JL, Ardon O, DeHart JL, Blackett J, Choudhary SK, Camerini D, Nghiem P, Planelles V. Human Immunodeficiency Virus Type I Vpr-mediated G2 Arrest Requires Rad 17 and Hus1 and Induces Nuclear BRCA1 and Gamma-H2AX focus foration. Mol Cell Biol. 24(21):9286-94, 2004. [pdf]
  1. Bradner JE, McPherson OM, Mazitschek R, Barnes-Seean D, Shen JP, Dhaliwal J, Stevenson KE, Duffner JL, Park SB, Neuberg DS, Nghiem P, Schreiber SL, Koehler AN. A Robust Small-molecule Microarray Platform for Screening Cell Lysates. Chem Biol. 13(5):493-504, 2006. [pdf]
  1. Boswell SA, Ongusaha PP, Nghiem P, Lee SW. The Protective Role of a Small GTPase RhoE Against UVB-induced DNA Damage in Keratinocytes. J Biol Chem. 282(7):4850-4858, 2007. [pdf]

  2. *Kawasumi M, Nghiem P.  Chemical genetics: Elucidating biological systems with small molecules.  J Invest Dermatol. 127(7):1577-84, 2007. [pdf]

  3. *Koo S-W, Hirakawa S, Fujii S, Kawasumi M, Nghiem P.  Protection from photodamage by topical application of caffeine after UV. Br J Dermatol. 156:957, 2007. [pdf]

  4. *Lu YP, Lou YR, Peng QY, Xie JG, Nghiem P, Conney AH. Effect of Caffeine on the ATR/Chk1 Pathway in the Epidermis of UVB-Irradiated Mice. Can Res. 68(7):2523-2529, 2008. [pdf]

  5. *Heffernan T, Kawasumi M, Blasina A, Anderes K, Conney A, Nghiem P.  ATR–Chk1 Pathway Inhibition Promotes Apoptosis after UV Treatment in Primary Human Keratinocytes: Potential Basis for the UV Protective Effects of Caffeine.  J Invest Dermatol. 2009 [pdf]

 

High (*) and Highest (**) relevance to on-going work in the laboratory