Paul Nghiem, M.D., Ph.D.

Education/Training:

  • 1998-2002: Howard Hughes Physician Postdoctoral Fellow, Dept of Chemistry and Chemical Biology
  • 1995-1998: Resident in Dermatology, Massachusetts General Hospital
  • 1994-1995: Intern in Medicine, Brigham & Women's Hospital
  • 1994: Ph.D. Stanford University, Program in Cancer Biology
  • 1994: M.D. Stanford University School of Medicine, Stanford, CA
  • 1986: A.B. Harvard University, Biological Sciences

Appointments/Certification:

  • 4/2015-present: Head, Division of Dermatology, Department of Medicine and
    George F. Odland Professor in Dermatology, Department of Medicine
    University of Washington, Seattle, WA
  • 2012-present: Professor, Dermatology/Medicine, University of Washington

  • 2007-2012: Associate Professor, Dermatology/Medicine, University of Washington
  • 2006-present: Director, Skin Oncology Clinical Program, Seattle Cancer Care Alliance, Seattle, WA
  • 2006-present: Affiliate Investigator, Clinical Research Division, Fred Hutchinson Cancer Research Center
  • 2006-2007: Assistant Professor, Dermatology/Medicine, University of Washington
  • 2002-2005: Assistant Biologist, Massachusetts General Hospital
  • 2002-2005: Assistant Professor of Dermatology, Harvard Medical School
  • 1999-present: Member, Society for Investigative Dermatology
  • 1998-2005: Attending Physician, Cutaneous Oncology, Dana-Farber Cancer Institute
  • 1998-2005: Associate Physician, Brigham & Women's Hospital
  • 1998-2002: Instructor in Dermatology, Dana-Farber Cancer Institute
  • 1998-2002: Instructor in Dermatology, Harvard Medical School
  • 1998-2002: Research Associate, Chemistry & Chemical Biology, Harvard Univ.
  • 1998: Fellow, American Academy of Dermatology
  • 1996-2005: Member, Harvard Dermatology Resident Selection Committee

Awards and Honors:

  • 2015: George F. Odland Chair in Dermatology
  • 2015: Alpha Omega Alpha (AOA) Medical Honor Society Member, AOA UW Chapter
  • 2014: Member, American Society for Clinical Investigation
  • 2012: American Cancer Society Legacy & Leadership Award: Find Cures Award
  • 2011-15: Michael Piepkorn Endowed Chair in Dermatology Research
  • 2011-12: Chairperson, NIH Cancer Etiology-B Study Section
  • 2009: NIH Mid-Career Investigator in Patient-Oriented Research (K24)
  • 2008-12: American Cancer Society Research Scholar
  • 2008: Faculty of 1000 - "Pharmacology and Drug Discovery" - Contributing Faculty Member
  • 2006: State of the Art Plenary Lecture, Society for Investigative Dermatology
  • 2005: Partners in Excellence Award (for directing the DFCI/Blum Skin Cancer Screening Program)
  • 2004-09: NIH Independent Scientist K02 Award
  • 2003: Departmental Service Award, Harvard University, Chemistry & Chemical Biology Department
  • 2002: Career Development Award, Harvard University/SPORE in Skin Cancer
  • 2000: Young Investigator in Dermatology Award, American Academy of Dermatology
  • 1999-04: NIH Clinician-Scientist K08 Award
  • 1998: Howard Hughes Med. Institute Physician Postdoctoral Fellow
  • 1998: European Society for Dermatological Research Travel Fellowship
  • 1997: Dermatology Basic Science Training Grant, Harvard University
  • 1989: Dean's Service Award, Stanford University
  • 1987: Medical Scholars Research Award, Stanford University
  • 1983: Detur Prize, Harvard College (academic top 2% after 1st year)
  • 1982-86: Dean's List, Harvard College, all semesters
  • 1981: Valedictorian, #1 in class of 300, Olympia High School

Invited seminars:

  • 7/25/2105   World Cutaneous Malignancies Congress, “Merkel Cell Carcinoma: How can the Merkel polyomavirus directly impact clinical management?,” Seattle, WA
  • 7/24/2105   World Cutaneous Malignancies Congress, “Merkel Cell Carcinoma: Clinical Features of an Immuno-sensitive Tumor,” Seattle, WA
  • 6/9/2105     World Congress of Dermatology, “WS19 - Rare Cutaneous Tumors, including Merkel Cell Carcinoma: Immune rationale and clinical trials for Merkel cell carcinoma,” Vancouver, BC
  • 6/9/2105     World Congress of Dermatology, “WS19 - Rare Cutaneous Tumors, including Merkel Cell Carcinoma: Merkel cell carcinoma overview & a polyomavirus antibody test to track disease recurrence,” Vancouver, BC
  • 5/8/2015: Seattle Investigative Dermatology, “Merkel polyomavirus and rationale for immunotherapy in Merkel cell carcinoma,” Atlanta, GA
  • 4/10/2015: Melanoma/Cutaneous Malignancies Meeting: "What’s New In Squamous and Merkel Cell Carcinomas," New York, NY
  • 3/22/2015: American Academy of Dermatology Annual Meeting: “Merkel Cell Polyomavirus, Immunity, and Targeted Therapy,” San Francisco, CA
  • 2/26/2015: Einstein Grand Rounds, "“Merkel cell carcinoma: Using the immune system to track and treat an often-lethal, polyomavirus-driven skin cancer," New York, NY
  • 3/5/14: University of Washington Laboratory Medicine Grand Rounds: “Clinical Utility of a Novel Assay for Tracking Tumor Burden in Merkel Cell Carcinoma,” Seattle, WA
  • 3/22/14: American Academy of Dermatology Annual Meeting: “Merkel Cell Polyomavirus, Immunity and Targeted Therapy,” Denver, CO
  • 3/22/14: American Academy of Dermatology Annual Meeting, Moderator: The latest in Dermatology Research, Denver, CO
  • 4/28/14: MGH/Harvard Cutaneous Biology Research Center Seminar Series: “Merkel cell carcinoma: New approaches to track and attack an often-lethal skin cancer based on Merkel polyomavirus-specific immune function & dysfunction,” Charlestown, MA
  • 5/8/14: Society of Investigative Dermatology Research in Cutaneous Surgery Session: “A novel single-fraction radiation approach for metastatic Merkel cell carcinoma is well tolerated and demonstrates strong efficacy linked to intact cellular immunity,” Albuquerque, NM
  • 5/10/14: Society of Investigative Dermatology Clinical Scholars Plenary Session: “Merkel cell carcinoma: Using the host immune response against a polyomavirus to track and attack an often lethal skin cancer,” Albuquerque, NM
  • 5/29/14: Shanghai Workshop for the Journal of Investigative Dermatology: “Merkel cell carcinoma: Intersection of immune dysfunction, infection and malignant progression”. Shanghai, China
  • 7/19/14: WA-OR Dermatology Meeting: “MCC: how to recognize it (still tricky); how to treat it (great progress!)”. Seattle, WA
  • 7/21/14: EMD Serono: R&D Site Lecture “Merkel cell carcinoma: Toward immune therapy in managing an often-lethal, polyomavirus-driven skin cancer". Boston, MA
  • 7/28/14: Sun Valley Science Spectrum: “Merkel cell carcinoma: Using a Virus to target a Cancer". Gimlet, ID
  • 8/24/14: Vaccines Plenary Lecture: “Merkel cell carcinoma: Using the Immune System to Track and Treat an often-lethal polyomavirus-driven skin cancer". Seattle, WA
  • 10/9/14: Case Western Skin Disease Research Center’s (SDRC) Lecture Series: “Merkel cell carcinoma: Toward multi-disciplinary and synergistic immune therapy approaches for an often-lethal, virus-driven skin cancer". Cleveland, OH
  • 10/22/14: University of Washington School of Medicine Radiation Oncology Grand Rounds: “Merkel cell carcinoma: Toward defining the optimal role of radiation in the adjuvant and metastatic settings",” Seattle, WA
  • 10/29/14: Third Annual World Cutaneous Malignancies Congress, Prevention and Early Detection Section Lecture: “A new serologic assay for early detection of recurrent MCC” San Francisco, CA
  • 1/30/2015: Pfizer, “Merkel cell carcinoma: etiology, immune evasion mechanisms, and early data supporting immunotherapy of an aggressive, polyomavirus-driven skin cancer” San Diego, CA
  • 1/27/14: University of Washington Molecular Medicine Seminar Series: “Merkel Cell Carcinoma: Improving Management of an aggressive virus-driven Skin Cancer with multidisciplinary team science,” Seattle, WA
  • 1/18/14: University of Washington Radiology Body Imaging Monthly Lecture: “Merkel Cell Carcinoma: Toward Optimal Management of an often lethal Skin Cancer,” Seattle, WA
  • 12/14/13: Society for Immune Therapy for Cancer (SITC) Advances in Cancer Immunotherapy (ACI) Regional Program, "Immunology & Immunotherapy of Viral-Related Cancers," Seattle, WA
  • 11/9/13: Allan H. Conney Memorial Symposium, "12 years of a wonderful (but unlikely) collaboration on mechanisms of caffeine's ability to block UV carcinogenesis," Robert Wood Johnson Medical School at Rutgers, The State University of New Jersey, New Brunswick, NJ
  • 11/7/13: University of Pennsylvania M. H. Samitz Lectureship in Cutaneous Medicine, "Merkel cell carcinoma: Toward multi-disciplinary and synergistic immune therapy approaches for an often-lethal skin cancer," Philadelphia, PA
  • 11/5/13: University of Washington Department of Pharmacology Seminar, "A Chemical Genetic Screen Reveals Mechanistically Novel Inhibitors of DNA Damage Signaling by ATR/ATM Kinases," Seattle, WA
  • 10/2/13: Fred Hutchinson Cancer Research Center CRD Immunotherapy Seminar Series," Merkel polyomavirus-specific immune function and dysfunction: Improving management of Merkel cell carcinoma with multidisciplinary team science," Seattle, WA
  • 7/27/13: Second Annual World Cutaneous Malignancies Congress, Merkel Cell Carcinoma Section Chair, Keynote Lecture: "Pathogenesis of Merkel cell carcinoma: an infectious etiology?" San Diego, CA
  • 7/27/13: Second Annual World Cutaneous Malignancies Congress, General Session II: Current Treatment Guidelines in Cutaneous Malignancies, "Merkel Cell Carcinoma," San Diego, CA
  • 3/1/13: American Academy of Dermatology Annual Meeting, Skin cancer viruses: bench to bedside: "Merkel polyomavirus-based tools to track & treat Merkel cell carcinoma," Miami Beach, FL
  • 3/1/13: American Academy of Dermatology Annual Meeting: Merkel cell carcinoma: diagnosis, Management and Controversies Scientific Session: "Introduction, epidemiology, staging," Miami Beach, FL
  • 3/1/13: American Academy of Dermatology Annual Meeting: Merkel cell carcinoma: diagnosis, Management and Controversies Scientific Session: "Merkel polyomavirus, immunity and future targeted therapies," Miami Beach, FL
  • 1/27/13: American Cancer Society, Great West Division "Mega-Event," "How American Cancer Society support impacts how we will treat rare and common cancers," Tukwila, WA
  • 12/4/12: AACR Tumor Immunology: Multidisciplinary science driving basic and clinical advances. Session: Engineered T cell therapies for cancer, "Merkel cell carcinoma therapy with viral oncoprotein-specific T cells in combination with immunostimulatory adjuvants," Intercontinental Hotel, Miami, FL
  • 9/21/12: University of Michigan School of Medicine Radiation Oncology "Bagel Talk": "Merkel cell carcinoma: toward optimal management of an often-lethal skin cancer," Ann Arbor, MI
  • 8/18/12: American Academy of Dermatology Summer Meeting Symposium: "Merkel cell carcinoma: Pathogenesis and targeted therapies," Boston, MA
  • 7/23/12: Medical Scientist Training Program (MSTP) 2012 Retreat Program: "Merkel cell carcinoma: Using immunobiology to track & treat a polyomavirus-driven, often-lethal skin cancer," Keynote Speaker, Sleeping Lady Mountain Retreat, Leavenworth, WA
  • 7/13/12: Society of Dermatology Physician Assistants (SDPA) Summer Dermatology Conference: "Merkel cell carcinoma: Toward optimal management of an often-lethal skin malignancy," Seattle, WA
  • 6/30/12: National Comprehensive Cancer Network (NCCN) 2012 Congress Series: Skin Cancers: "Management of Merkel cell Carcinoma," Tampa, FL
  • 6/21/12: Fred Hutchinson Cancer Research Center Viral Pathogenesis Symposium session: "Toward Merkel Polyomavirus - Targeted Immune Therapy for an Often-Lethal Skin Cancer," Seattle, WA
  • 5/17/12: Washington University Dermatology Visiting Professor, "Merkel cell carcinoma: Toward optimal management of an often-lethal skin cancer" and "Caffeine and skin cancer: What's behind and beyond the buzz?" St. Louis, MO
  • 5/11/12: Society of Investigative Dermatology Mini-Symposium: Human Clinical Research & Therapeutics session: "Merkel cell carcinoma therapy with viral oncoprotein-specific T cells in combination with immunostimulatory adjuvants." Raleigh, NC
  • 5/10/12: Society of Investigative Dermatology Symposium: "Merkel cell carcinoma: From virology & immunology toward rational therapy"; Organizer, Chair, & Speaker, Raleigh, NC
  • 4/26/12: Karolinska University Hospital, "Merkel cell carcinoma: Toward optimal management of an often-lethal skin cancer" Stockholm, Sweden
  • 4/25/12: Skanes University Hospital, "Merkel cell carcinoma: Toward optimal management of an often-lethal skin cancer," Malmo, Sweden
  • 4/24/12: Sahlgrenska University Hospital, "Merkel cell carcinoma: Toward optimal management of an often-lethal skin cancer," Gothenburg, Sweden
  • 2/9/2012: University of Washington South Lake Union Group TAPAS Seminar Series, "Merkel cell carcinoma: Using immunobiology to track & treat a polyomavirus-driven, often-lethal skin cancer," Seattle, WA
  • 10/6/11: Emory University Dermatology Grand Rounds, "Merkel cell carcinoma," Atlanta, GA
  • 9/7/11: University of California, Davis, Dermatology Grand Rounds, "Merkel cell carcinoma,Davis, CA
  • 8/2/11: Charite Medical University Visiting Professor & Seminar, "Merkel cell carcinoma," Berlin, Germany
  • 6/26/11: HemOnc Today Melanoma and Cutaneous Malignancies 2011, "Merkel Cell Carcinoma," New York, NY
  • 6/2/11: Overlake Hospital Grand Rounds, "Merkel cell carcinoma," Bellevue, WA
  • 5/12/11: South Sound Dermatology Association, "Merkel Cell Carcinoma," Olympia, WA
  • 5/5/11: Society for Investigative Dermatology (SID) Clinical Scholars Track: Plenary Session Presentation, "Reversal of local immune evasion mechanisms and regression of human Merkel cell carcinoma by intralesional injection of interferon-beta," Phoenix, AZ
  • 3/13/11: 35th Hawaii Dermatology Seminar, "The Good and The Bad of UV Radiation: Focus on Immune Suppressed Patients," Maui, HI
  • 3/13/11: 35th Hawaii Dermatology Seminar, "Merkel Cell Carcinoma Update," Maui, HI
  • 11/25/10: International Symposium: Advances in Oncologic Dermatology, Plenary Lecture, "Merkel cell carcinoma," Valencia, Spain
  • 11/11/10: Duhring Lecture, University of Pennsylvania, Dermatology Department, "Merkel cell carcinoma," Philadelphia, PA
  • 10/11/10: University of Cincinnati Dermatology Visiting Professor, "Merkel cell carcinoma: Toward Optimal Management," Cincinnati, OH
  • 6/6/10: American Society of Clinical Oncology, "Non-melanoma Skin Cancers," Speaker and session chair, Chicago, IL
  • 5/7/10: Society for Investigative Dermatology Symposium: "Emerging Mechanism-based Therapies for Skin Cancers"; Co-chair, "Merkel Cell Carcinoma: Identifying and Overcoming Cellular Immune Evasion Mechanisms in a Polyomavirus-associated Skin Cancer," Atlanta, GA
  • 5/7/10: Society for Investigative Dermatology Translational Research Symposium: "Personalized Genetics in Medicine: Are we there yet?" Chair, Introduction, Atlanta, GA
  • 4/26/10: U.C. Irvine Visiting Professor; "Merkel Cell Carcinoma: Toward Optimal Management of an Often-Lethal Skin Malignancy," Irvine, CA
  • 4/23/10: National Cancer Registrars Association, 36th Annual Education Conference Plenary Lecture; "Merkel Cell Carcinoma: Toward Optimal Management of the Most Lethal Skin Malignancy," Palm Springs, CA
  • 4/21/10: Wayne State University Dermatology Visiting Professor, "Merkel cell carcinoma," Detroit, MI
  • 3/17/10: Seattle Dermatologic Society; "Caffeine & skin cancer: What's behind and beyond the buzz?" Seattle, WA
  • 11/12/09: Duke University Dermatology Visiting Professor, "Merkel cell carcinoma," Durham, NC
  • 11/4/09: University of Washington "Pathology Presents" Series, "Merkel Cell Carcinoma and a New Polyomavirus: Mechanisms of Immune Escape by an Often-lethal Skin Malignancy," Seattle, WA
  • 10/23/09: Southwest Oncology Group Melanoma Meeting, "Merkel Cell Carcinoma: Biology, Prognosis & Toward Prospective Studies," Chicago, IL
  • 10/21/09: Yale Dermatology Seminar Series; "Caffeine and Skin Cancer: What's the Buzz?" New Haven, CT
  • 10/21/09: Yale Dermatology Visiting Professor Lecture Series; "Merkel Cell Carcinoma: Toward Optimal Management of the Most Lethal Skin Malignancy," New Haven, CT New Haven, CT
  • 10/7/09: UW Medicine & Seattle Public Library Medical Lecture Series, "Does Caffeine Reduce the Risk of Skin Cancer?" Seattle, WA
  • 8/13/09: Pacific Dermatologic Association, "MCC: Toward Optimal Management of the Most Lethal Skin Malignancy," Portland, OR
  • 2/26/09: Dermatologic Society of Greater New York, "Merkel cell carcinoma: Toward Improved Understanding and Management of the Most Lethal Skin Malignancy." New York, NY
  • 1/30/09: Dermatology Foundation Clinical Symposium, "Merkel cell carcinoma," "Dermatofibrosarcoma Protuberans" and "Challenging Cases in Skin Oncology," Naples, FL
  • 1/20/09: Loyola University, Cancer Center Basic Science Seminar, "ATR in the Cell Cycle of Normal and Cancer Cells: An Achilles Heel for Cancer?" Chicago, IL
  • 1/9/09: NIH Workshop on Merkel cell carcinoma. "Clinical Presentation, Staging, Treatment and Prognosis of Merkel cell carcinoma." Rockville, MD
  • 11/22/08: 2nd Worldwide Meeting of Melanoma Centers, "Management of Merkel Cell Carcinoma in a Melanoma Center," Moffitt Cancer Center, Tampa, FL
  • 9/2/08: Keck School of Medicine, University of Southern California, Department of Dermatology Grand Rounds, "Merkel cell carcinoma: Toward Improved Management of the Most Lethal Skin Malignancy," Los Angeles, CA
  • 6/27/08: Julius Maximilians University, Department of Dermatology, "Clinical and Biological Aspects of Merkel Cell Carcinoma," Wuerzburg, Germany
  • 6/25/08: Keynote Lecture: Societe du Cancer EuroCancer 22nd annual meeting, 2008, "Merkel cell carcinoma," Paris, France
  • 5/1/08: Cutaneous Oncology Update 2008, ACMS 40th Annual Meeting, "Merkel cell carcinoma: Introduction to the first proposed Merkel cell carcinoma American Joint Commission on Cancer staging system," Vancouver BC, Canada
  • 1/20/07: American Joint Committee on Cancer: "Merkel Cell Carcinoma and the AJCC." Commission on Cancer, Chicago, IL
  • 12/2/06: Issues in Dermatology: (Presidential Priorities Meeting of the American Academy of Dermatology), "Translational research and the future of the American Academy of Dermatology," Phoenix, AZ
  • 2/06: Seattle Dermatologic Society, "Merkel cell carcinoma: Toward optimal management of the most lethal skin malignancy," Seattle, WA
  • 11/6/06: Housestaff Conferences, "Dermatologic Manifestations of Infectious Disease," SMC-Providence, Seattle, WA
  • 9/28/06: Medical Grand Rounds, University of Washington Medical Center, "Merkel cell carcinoma: Toward optimal management of the most lethal skin malignancy," Seattle, WA
  • 5/5/06: Society for Investigative Dermatology, State of the Art Plenary Lecture, "Chemical genetics: A new discovery tool in skin research," Philadelphia, PA
  • 1/20/05: Rutgers University, Department of Biological Chemistry, Piscataway, NJ
  • 9/29/04: Johns Hopkins Department of Pharmacology and Molecular Sciences, Baltimore MD
  • 12/8/03: Pfizer, Oncology Division, La Jolla, CA
  • 11/13/03: Duhring Lecture, University of Pennsylvania, Dermatology Department, Philadelphia, PA
  • 10/10/03: Tohoku University School of Medicine, Sendai, Japan
  • 10/9/03: Keio University Dept of Pharmacology and Neurosciences Tokyo, Japan
  • 10/8/03: Shiseido Research Center at Shin-Yokohama, Japan
  • 10/8/03: Kanazawa Hakkei Campus; Shiseido Research Center, Yokohama, Japan
  • 3/20/03: Stanford University Pharmacology Department, Stanford, CA
  • 1/24/03: UCLA Pharmacology Department, Los Angeles, CA
  • 9/12/02: Initiative for Chemical Genetics, Whitehead Genome Center, MIT, Cambridge, MA
  • 8/30/02: Nat'l Cancer Institute, Dermatology Branch, NIH, Bethesda, MD
  • 8/9/02: Dept of Biochemistry, University of Minnesota, Minneapolis, MN
  • 6/18/02: Rutgers University, Dept of Chemical Biology, Piscataway, NJ
  • 6/7/02: University of Minnesota Medical School, Minneapolis, MN
  • 4/16/02: Medical College of Wisconsin, Milwaukee, WI
  • 4/8/02: Institute for Chemistry and Chemical Biology, Harvard University, Cambridge, MA
  • 3/6/02: Gordon Conference, Mutagenesis & Carcinogenesis, Ventura, CA
  • 2/14/02: University of Massachusetts Medical School, Worcester, MA
  • 12/21/01: Fred Hutchinson Cancer Research Institute, Seattle, WA
  • 12/3/01: Boston University Medical School, Boston, MA
  • 11/29/01: Mass General Hospital-East, CBRC, Charlestown, MA
  • 11/13/01: Emory University, Atlanta, GA
  • 11/6/01: Millennium Pharmaceuticals, Cambridge, MA
  • 10/26/01: University of Washington, Seattle, WA
  • 10/25/01: Washington University, St Louis, MO
  • 10/23/01: Photomedicine Seminar of the Wellman Labs, MGH, Boston, MA
  • 8/17/01: Rockefeller University, New York, NY
  • 7/26/01: University of Michigan, Ann Arbor, MI
  • 7/13/01: Case Western Reserve University, Cleveland, OH
  • 7/10/01: Merck Research Labs, Westpoint, PA
  • 4/30/01: MD Anderson Cancer Center, Houston, TX